A Novel Molecular Imaging Modality: Magnetic Particle Imaging报告人:
Dr. Jing Zhong is an associate professor in School of Instrumentation and Optoelectronic Engineering at Beihang University. He has got his bachelor and PhD degrees from 2009 to 2014 in Huazhong University of Science and Technology. He has obtained postdoc fellowship from the Japan Society for the Promotion of Science (JSPS) and Humboldt Fellowship from Alexander von Humboldt foundation. In addition, he has worked as a PI of a research project on magnetic particle imaging from German Research Foundation. His research interests include electromagnetic imaging technique and instrumentation, advanced sensing technique, noninvasive temperature imaging, nanomagnetic modeling, magnetic particle imaging and its biomedical applications (biomolecule imaging, cell tracking and cancer theranostics). So far, He has published 24 SCI papers and held 6 international patents (USA, Japan, Europe) and 5 Chinese patents. He has received “Best Paper Oral Award” in 2015 IEEE NANO conference and the 1st poster price in 2018 German Ferrofluid Workshop.
Magnetic particle imaging (MPI) is a novel molecular imaging modality, which quantitatively visualizes the spatial distribution of in vivo superparamagnetic iron oxide nanoparticles (SPIONs) with direct measurement of the nonlinear magnetic response of the SPIONs. Previous approaches have shown that MPI allows high sensitivity of about 10 ng iron, high spatial resolution of 0.5 mm and high temporal resolution of about 22 ms to acquire one 3D image. To date, MPI has shown its great promise in biomedical applications, including targeted drug delivery, magnetic hyperthermia for cancer therapy, stem/immune cells tracking and early diagnostics of cancer.
This study reports on the development of an MPI scanner, including MPI principle and hardware design. Different phantom experiments are performed with a custom-built MPI scanner to evaluate the spatial resolution and limit of detection (LOD). Experimental results demonstrate that our MPI approach allows to resolve two lines with a gap of 0.5 mm and an LOD of 274 ng iron. Moreover, the temperature sensitivity of the SPION spectra induced in ac magnetic fields is investigated to achieve non-invasive temperature imaging in vivo. In addition, the SPIONs are functionalized with different antibody/antigen to quantitatively visualize the spatial distribution of antigens/antibodies, as well as the tracking of CD4 T cells. We envisage that MPI is one of the most promising approaches for disease diagnostic and therapy.