报告题目:

Fabrication of Human organoid and organ-on-a-chip based on innervation

报告人:

郑付印

所在单位:

School of Biological Science and Medical Engineering, Beihang University

个人简介:

郑付印，副教授，博士生导师，北京市科技新星，江苏省“优博”和北航“青拔”。一直面向生命健康，脑科学和空天科技交叉领域开展了前沿创新研究，重点围绕地基和面向空间应用的人体类器官和器官芯片，3D和4D生物打印，仿生结构色功能材料和载人航天医学工程等领域。主持和参与10项国家自然科学基金项目（重点2项，面上2项，青年2项），在PNAS（IF=11.205），Adv. Mater.（IF=30.849，2 篇），Biomaterials（IF=12.479），Small    (IF=13.281)和Research（Science首本合作期刊）等发表30余篇学术论文，总引用1000余次，已授权10项国家发明专利。

Abstract:

Organoids and organ-on-a-chips have broad application prospects in the fields of new drug research and development, disease model, personalized medicine and manned aerospace medicine. We have constructed a series of multi-organ on a chip that simulating the microphysiological structure of vascularized organs, such as splenic blood sinus, microvascular tumor and blood-retinal-barrier, ect.. We also constructed three-dimensional (3D) vascularized brain organoids and fused organoids using induced pluripotent stem cells and reproduced powerful physiological and functional coupling between nerves and target tissues (blood vessels, muscles and myocardium) or target organs that combined with optogenetics, 3D and 4D bioprinting. The fabricated organ-on-a-chips are used to construct in vitro models of neurovascular units, neuromuscular junctions and neuromyocardial junctions, and intergreted with sensors, electrophysiological stimulation and on-line monitoring for high-throughput drug screening application.