Study on a new sonosensitizer Mn@T-BTO for sonodynamic therapy of tumor报告人:
School of Mechatronic Engineering and Automation, Beihang University
Peng Zhang is a postdoctoral fellow in School of Mechatronic Engineering and Automation, Beihang University. He received the BS degree and MS degree from Northeast Agricultural University, Harbin, China, in 2013 and 2016 respectively, and the Ph.D. degree from Beijing Institute of Technology, Beijing, China, in 2020. From 2020 till now, he worked as a postdoctoral researcher in Beihang University. His research interests include Micro/nano robotics, applications in tumor and neurodegenerative diseases related fields.
Dr. Zhang has published more than 10 papers in peer-reviewed journals, including Nanomaterials, Industrial Crops and Products, Frontiers In Aging Neuroscience. He has given 5 presentations in international conferences (IAA Humans in Space Symposium, CIE). He received the Best Paper Award at the Life Electronics Branch of Chinese Institute of Electronics in2018.
Sonodynamic therapy has non-invasive, slight energy attenuation and high tissue penetration ability. Tetragonal phase barium titanate nanocrystals (T-BTO) are a typical piezoelectric material, which can effectively catalyze the generation of ROS under ultrasonic radiation, thereby eradicating tumors. However, T-BTO lacks tumor targeting and imaging. At the same time, T-BTO, which is freed from the blood circulation to other tissues, will cause safety hazards to healthy tissues during the process of sonodynamic therapy. We designed and synthesized a manganese-doped barium titanate (Mn@T-BTO), which does not have piezoelectricity. Compared with normal tissues, the use of tumor microenvironment has the characteristics of low pH. When Mn@T-BTO dissociates into the tumor tissue, it will be separated into water-soluble Mn2+ ions, and at the same time release the piezoelectric T-BTO, which improves the tumor targeting of nanocrystals. The low-priced divalent manganese ions are partially oxidized to high-priced, thereby promoting the production of ROS. It has a synergistic effect with T-BTO to produce ROS and accelerates the ablation of tumor tissue. At the same time, the release of manganese ions can significantly improve T1-weighted MRI of tumor tissue. This material solves the problem of targeting and safety of T-BTO as a sonosensitizer.