Building of magnetosomes and magnetotactic bacteria application platform报告人:
School of Mechanical Engineering & Automation, Beihang University
Junjie Xu is a postdoctor in School of Mechanical Engineering & Automation, Beihang University. She received the B.S. degree and M.S. degree from Huaibei Normal University, in 2013 and 2016 respectively, and the Ph.D. degree from China Agricultural University, in 2021. Her research focuses on building of magnetosomes and magnetotactic bacteria application platform.
Magnetotactic bacteria (MTB) are ubiquitous aquatic microorganisms that incorporate iron from their environment to synthesize intracellular nanoparticles of magnetite (Fe3O4) or greigite (Fe3S4) (termed magnetosomes; BMPs)in a genetically controlled manner. BMPs magnetic phases that allow MTB to swim towards redox transitions zones where they thrive. Unlike chemically-synthesized magnetite nanoparticles, BMPs magnetite crystals are stable single-magnetic domains and are thus permanently magnetic at ambient temperature, are of high chemical purity, and display a narrow size range and consistent crystal morphology, making them ideal biotechnological materials. Here our research focused on (1) construction of engineering BMPs. We successfully constructed biotin/ streptavidin/ protein A labeled BMPs, and apply in pathogen detection and cell sorting respectively. (2) Synthesis of multifunctional composites based on BMPs. We firstly reported green synthesis of Janus-like noble-metal-magnetic nanohybrids via BMPs. (3)Increase BMPs production. High yield of BMPs was the foundation for BMPs and MTB application. One of our research focused on optimized MTB culture conditions to increase BMP yield. Nowadays our BMPs yield reached the highest one. (4) Construction of magneto-aerotactic microrobots. MTB prefer to live in low oxygen concentration region, swim along the magnetic field and have flagella propulsion, making it to be an ideal biorobot. We used MTB as nanorobots delivery drugs for cancer treatment.