Cell manipulations base on the magnetic,acoustic field for biomedical application报告人:
School of Mechatronic Engineering and Automation, Beihang University
Xue Bai is an Postdoctor in School of Mechatronic Engineering and Automation, Beihang University. He received the B.S. degree from Inner Mongolia University, Huhhot, in 2011. and the M.S. degree from Lanzhou University, Lanzhou, China, in 2014. She got the Ph.D. degree from University of Chinese Academy of science, Beijing, China, in 2019. Now, she worked as a postdoctoral researcher in Beihang University science 2019. His research interests include Micro/nano robotics, Microfluidic devices and Bio-Nano interaction.
Dr. Bai has published more than 40 papers in peer-reviewed journals, including Small、Nanoscale、Nanomedicine-NBM and Lab on a chip. She has given presentations in IEEE IROS 2020. She was invited to review articles for Advanced Science, environment health perspective.
The study of cells attracts considerable attention because the cell is the basic structural, functional, and biological unit of all known living organisms. The importance of cell manipulation and cultivation has been increasing rapidly in various fields, such as drug discovery, regenerative medicine, and investigation of new energy sources. Here, cell manipulation based on magnetic and acoustic will be introduced. Firstly, we fabricated magnetized cell robots comprised of mouse macrophages and iron nanoparticle functionalized with doxorubicin and indocyanine green. These functionalized nanoparticles were wrapped in a liposome, enabling high concentrations of doxorubicin to be carried with minimal adverse effect. A cascaded drug release system was designed based on selective activation of the photothermal conversion effect in indocyanine green, ensuring that the effect of doxorubicin was targeted precisely to tumors. We also developed a magnetic control platform consisting of four electromagnetic coils, for improved speed and positioning accuracy in three dimensions. With this scheme, a tumor growth inhibition rate of ~91% was obtained for Balb/c mice, with the drug and nanoparticle concentrations, and magnetic field. Secondly, A postoperative evaluation system based on the long-term dynamic detection of CTCs helps in guiding the postoperative treatment of tumours in real time and preventing metastases and recurrence of tumours after treatment. In this study, a simple, rapid, and low-cost postoperative evaluation system was established based on the number of CTCs captured by a label-free acoustic separation device from whole blood samples of mice, of which breast tumours were surgically removed, and tumour metastasis was successfully predicted。