Research on the bioprinting process of corneal structure based on trajectory pattern planning报告人:
School of Mechatronics Engineering, Harbin Institute of Technology
Efficient and reproducible construction of in vitro biological tissues and organs has always been a difficult problem in traditional tissue engineering. The emergence of bioprinting technology provides a new research approach for the fabrication of complex tissue structures. So far, the research on bioprinting technology has made impressive progress in printing materials, process parameters, and structural molding, etc. However, the influence of the design of trajectory path for nozzle during the printing process on the production qualities is still rarely mentioned. This work focuses on the effect of the personalized design of printing track and the optimized combination of trajectory patterns on the dimensional accuracy and surface quality of the printed target to conceive a viable bioprinting strategy. Based on the mechanical and rheological characterization of the self-designed hydrogel, the printability evaluation and printing parameter optimization of the hydrogel materials were realized through polygonal pattern printing. The corneal structure, with the physiological function highly dependent on the shape characteristics and geometric dimension, was selected as the printing target, and two different types of printing trajectories featured by the concentric-circle pattern and the parallel-line pattern were designed respectively. The comparison of the molding quality indicates that the print trajectory with parallel-line pattern can offer an advantage of even flow and stable motion, which helps to form a high-quality surface at the center of the corneal structure. Based on the above research work, we also explored the feasibility of synergic printing combining multi-pattern trajectory with multiple materials, which may provide a reference for the subsequent work researching into the influence of regionalized printing using specific materials on the overall mechanical properties of complex structures.