报告题目:

Research on the bioprinting process of corneal structure based on trajectory pattern planning

报告人:

Chunya Wu

所在单位:

School of Mechatronics Engineering, Harbin Institute of Technology

个人简介:

吴春亚，教授/博士生导师。哈尔滨工业大学机电工程学院机械制造系副主任、国家级机械工程实验教学示范中心及国家级高端装备制造虚拟仿真实验教学中心副主任。主要研究方向为超精密与微纳米制造技术，面向国家重大需求和人民生命健康，开展太赫兹慢波微结构超精密加工工艺装备、含能材料界面性能调控、植入材料生物相容性优化等方面研究。主持国家自然科学基金青年/面上项目、黑龙江省优秀青年基金、装备发展部共性技术等项目共计15项；作为技术骨干，参研国家重点研发计划、国家863计划重点项目、国家科技重大专项等近10项。获黑龙江省自然科学二等奖1项（排3）、黑龙江省高校科技奖二等奖1项（排1）。在国内外刊物上发表学术论文50余篇，SCI收录近40篇，发表中文综述论文5篇（机械工程学报3篇）。申请国家发明专利20项，授权11项，转化2项。主持教学改革项目4项，获教学竞赛奖3项，副主编专业手册1部，参编教材3部。

Abstract：

Efficient and reproducible construction of in vitro biological tissues and organs has always been a difficult problem in traditional tissue engineering. The emergence of bioprinting technology provides a new research approach for the fabrication of complex tissue structures. So far, the research on bioprinting technology has made impressive progress in printing materials, process parameters, and structural molding, etc. However, the influence of the design of trajectory path for nozzle during the printing process on the production qualities is still rarely mentioned. This work focuses on the effect of the personalized design of printing track and the optimized combination of trajectory patterns on the dimensional accuracy and surface quality of the printed target to conceive a viable bioprinting strategy. Based on the mechanical and rheological characterization of the self-designed hydrogel, the printability evaluation and printing parameter optimization of the hydrogel materials were realized through polygonal pattern printing. The corneal structure, with the physiological function highly dependent on the shape characteristics and geometric dimension, was selected as the printing target, and two different types of printing trajectories featured by the concentric-circle pattern and the parallel-line pattern were designed respectively. The comparison of the molding quality indicates that the print trajectory with parallel-line pattern can offer an advantage of even flow and stable motion, which helps to form a high-quality surface at the center of the corneal structure. Based on the above research work, we also explored the feasibility of synergic printing combining multi-pattern trajectory with multiple materials, which may provide a reference for the subsequent work researching into the influence of regionalized printing using specific materials on the overall mechanical properties of complex structures.