报告题目:

重构血管化肝脏模型评估介入化疗栓塞 Reconstructed vascularized liver tumor model for transarterial chemoembolization evaluation

报告人:

郭琼玉

所在单位:

 南方科技大学

个人简介:

郭琼玉，助理教授，博士生导师。长期注重于高分子生物材料在转化医学方向的研发，将其应用于多个具有挑战性的生物医学课题，在可移植人工角膜、介入栓塞材料、可降解血管支架、记忆性纳米材料、骨修复以及细胞调控等领域里取得了突出的研究成果。郭琼玉教授是深圳市海外高层次人才“孔雀计划”B类获得者，发表学术论文27篇，被引用>800次，申请专利12项，授权6项，其中可移植人工角膜的研究成果在全球提交了多项专利申请，已经获得包括中国、日本和欧洲等多个国家的专利授权。现任中国医师协会介入医师分会第三届委员会介入医学工程与生物技术学组委员（2021年-2024年），广东省生物医学工程学会智能介入医学分会常务委员（2020年-2023年）。

Abstract：

Endovascular intervention, which applies image-guided catheter-based minimal invasive treatment procedures, has dramatically transformed the management of a multitude of vascular diseases and hypervascular tumors over past decades. However, the development of interventional treatment strategies strongly depends on animal models and clinical trials, largely lacking in vitro models to provide sufficient preclinical evaluations for a critical interrogation of the therapeutic modalities. Here we reconstruct a translucent 3D liver tumor model based on hepatic decellularized scaffold for transarterial chemoembolization (TACE) evaluation, a widely applied endovascular interventional therapy that has become the mainstay treatment for unresectable hepatocellular carcinoma (HCC). The utility of this novel model encompasses three main superior capacities: (1) testing both embolization and chemotherapy performances of clinically relevant TACE agents; (2) maintaining a translucency appearance suitable for in vitro monitoring using general available microscopic imaging tools; (3) examining tumor microenvironment under the balance between drug diffusion and nutrient supply.