Magnetic-DCR3 nanoparticles as a new strategy for efficient targeting hepatocellular carcinoma报告人:
School of Mechanical Engineering & Automation, Beihang University.
Lina Jia is a postdoctor in School of Mechanical Engineering & Automation, Beihang University. She received the B.S. degree from Hebei Agricultural University in 2014 and Ph.D. degree from China Agricultural University in 2020. Her research focuses on application of field controlled micro nano robot for targeted drug delivery in tumor therapy.
Dr. Jia has published more than 10 papers in peer-reviewed journals, including Cell、Nature communications and small.
Hepatocellular carcinoma (HCC) is a major histological subtype of liver cancer, accounting for 90% of primary liver cancer. A variety of therapy methods was used, however, the liver cancer death rate still increase every year. Thus, finding a safe and effective treatment has become a hot spot in current research. Decoy receptor 3 (DCR3) is upregulated in many malignant tumors, which can inhibit the apoptosis of dendritic cells, regulate immune function and induce angiogenesis. Thus, DCR3 is expected to be used as a small molecule targeting agent to effectively deliver the drug to the tumor site and improve the effect of tumor therapy. Magnetic nanoparticles can effectively and precisely penetrate into the tumor tissue under magnetic field.