Sweat Gland Restoration for Functional Skin Repair and Regeneration报告人:
Department of Medical Innovation, Chinese PLA General Hospital.
Xiaoyan Sun, M.D. PhD. Professor of the Wound Healing & Regenerative Medicine Research Center, Department of Medical Innovation, Chinese PLA General Hospital.
Her research interests include skin wound healing, stem cell fate manipulation, cellular reprogramming, and biomaterial-based functional skin repair and regeneration. In the past five years, Prof. Sun has authored or co-authored over 20 publications in journals and conferences, such as Advanced Science, Biomaterials. She was a recipient of the Beijing Novel Programme (Beijing Municipal Science & Technology Commission) in 2008 and the Army’s Distinguished Young Scientist Programme in 2010. Dr. Sun is the youth committee of the Chinese Tissue Repair Society (CTRS) and serves as the vice chairman of the Rehabilitation and Functional Reconstruction Society.
Sweat glands (SwGs) are essential for human survival. However, for patients with large skin defects, the severe injury and following hypertrophic scar formation usually causes disruption to the overall skin architecture and loss of SwGs, which dramatically decreased a patient's quality of life. Therefore, restoring SwGs represents a significant issue in the functional wound care of extensive skin defects.
Dr. Sun currently attempt to combine regenerative medicine with tissue engineering technology to innovate systematic approaches for the repair and regeneration of damaged skin structurally and functionally, which involves: 1) A platform of reprogramming-based strategy to create robust and consistent high-quality SwG lineages with therapeutic potentials for the clinical and translational applications in regenerating SwGs; 2) The design of complex systems that could bio-mimic the structural complexity and physiology of native skin tissues which create a favorable external microenvironment for modulating SwG specification and maturation via biomaterials with bio-loading technologies; 3) The development of a custom-designing organoid-based platform that allow cost-effective generation of transplantable organoids from individual patients without requiring ex vivo expansion of difficult-to-preserve primary SwG cells.