报告题目:

Organ-on-a-Chip Technology for Pharmacodynamics and Toxicology Research

报告人:

Xiuli ZHANG

所在单位:

College of Pharmaceutical Science, Soochow University

Biography:

Professor Xiuli ZHANG graduated from Nankai University in 2000, and received her Ph.D. from Dalian Institute of Chemical Physics, Chinese Academy of Sciences. On May 2019, Prof. Xiuli ZHANG moved from Dalian Institute of Chemical Physics, Chinese Academy of Sciences to Soochow University. Her new lab in Soochow University focuses on development of new methods and platforms for drug discovery from natural products, exploiting technologies including organ-on-a-chip, 3D bioprinting, organoid etc. She authored 99 original research papers in international journals, and have 40 patents in which 20 have been authorized. One article was selected as one of "First 100 Most Influential Outstanding International Academic Papers in China". She has undertaken many projects from Ministry of Science and Technology and National Natural Science Foundation of China. She was invited to review some international SCI journals such as Frontiers in Pharmacology，Analytical & Bioanalytical Chemistry, and RSC Advances.

Abstract：

The biomimetic ability of in vitro evaluation methods is essential to improve the efficiency of drug discovery. High biomimetic evaluation methods are not only a requirement for pharmacodynamic evaluation, but also the basis for in-depth toxicological research. Therefore, how to improve the biomimetic properties of in vitro models has always been an important issue facing new drug research. The reporters used organ-on-a-chip technology to develop a series of physiological and pathological models, and applied them to activity efficacy and toxicity evaluation. Recent research progress includes: (1) The construction of a toxicological evaluation platform based on liver-on-a-chip, kidney-on-a-chip and heart-on-a-chip, which can realize the systematic toxicity evaluation of different organs of candidate drugs. 2) A pathological liver-on-a-chip is constructed, which can be used to determine the dose of hepatoprotective drugs that are effective without liver damage. 3) An intestinal-on-a-chip is constructed, which can be used in conjunction with a liver-on-a-chip to study the efficacy/toxicity of the drug after the intestinal metabolism.