4D printed Bio-piezoelectric scaffolds for Synergistic Sono-electrodynamics Tumor Therapy报告人:
School of Materials Science and Engineering, Huazhong University of Science and Technology
Annan Chen，Huazhong University of Science and Technology
Associate researcher, mainly engaged in additive manufacturing and performance research of bioceramics. Currently, as the first author and corresponding author, he has published 18 SCI papers in J. Eur. Ceram. Soc., J. Am. Ceram. Soc. and other well-known journals in the field of materials, with a total of more than 300 citations. He is currently the subject editor of Materials journals, and reviewers of journals such as Addit. Manuf., J. Eur. Ceram. Soc., J. Alloy. Compd., etc.
Construction of multifunctional materials with bone-tissue remodeling and bone-tumor killing capacities remains a substantial challenge for bone tumor treatment. Herein, we report on a 4D printing approach to obtain highly electroactive bio-piezoelectric material scaffolds (Barium Calcium Zirconate Titanate, BCZT, d33~ 480 pC/N). A non-invasive and convenient ultrasonic stimulation is applied to induce the scaffold to establish a strong built-in electric field. The intensity of the endogenous electric field is controlled by designing scaffold features (such as unit cell type, volume fraction, and structural directionality) and adjusting ultrasonic parameters (such as frequency and intensity). Further, we investigate the osteogenesis promotion effect of the 4D printed BCZT scaffolds, and reveal the mechanisms for the ROS generation efficiency equivalent to 1+1>2 involved in synergistic sono-electrodynamics therapy of tumors, providing a highly desirable universal solution for the efficient and non-invasive treatment of bone tumors.
Figure 1. Schematic illustration of the preparation of bio-piezoelectric scaffold and its principle of bone repair and tumor treatment.