Effect of Porous Structure on Mechanical Properties, In Vitro Corrosion and Cell Viability of Biodegradable Metal Scaffolds Fabricated by Laser Powder Bed Fusion报告人:
2009年毕业于日本广岛大学，获得机械工程博士学位。目前主要从事激光增材制造技术和生物可降解金属材料研究，承担国家和企事业单位相关课题30余项，在Bioactive Materials, Acta Biomaterialia, Additive Manufacturing等发表学术论文50余篇。
Additively manufactured biodegradable metal scaffolds (AM-BMS) are regarded as a revolutionary technology for repairing bone defects, since they provide structural freedom of customized design and bioactive function to promote bone growth. In this work, porous scaffolds of diamond (D) units with porosity 70%, 80% and 90%, as well as body centered cube (BCC) and Gyroid (G) units with the constant porosity 80% were designed, and fabricated by laser powder bed fusion (L-PBF) using Zn-0.7Li powder. The compressive strength and elastic modulus decreased with increasing the porosity, while both of them ranked as BCC>G>D with the same 80% porosity. G samples exhibited uniform stress distribution and excellent energy absorption. According to 28-day immersion test, the weight loss ratio increased with increasing the porosity, and was 50% higher of BCC than that of G samples. The G samples showed uniform corrosion in space and the lowest loss of strength after the immersion. Nevertheless, osteoblastic cells showed a more spreading and healthier morphology when adhering to G samples compared to BCC and D samples. Numerical simulation was carried out to analyze the different compressive properties and degradation behavior, and the calculation results corresponded with the experimental data within an acceptable error. Therefore, it can be developed further in the future to predict the mechanical and biodegradable performance of BMS and optimize the structural design to satisfy the personalized clinical needs.
Figure 1.Weight loss (a, b) compressive strength (c, d) and corrosion products (e) of scaffolds with different structure during 28-day immersion