报告题目:

Alveolar bone repair of rhesus monkeys by using BMP-2 gene and mesenchymal stem cells loaded three-dimensional printed bioglass scaffold

报告人:

许为康

所在单位:

广东省科学院生物与医学工程研究所

个人简介：

许为康，博士，高级工程师，广东省科学院生物与医学工程研究所智能植介入材料团队负责人。主要从事新型骨科植入材料、组织工程化微球和骨组织工程支架基础和应用基础研究，主持国家自然科学基金、博士后基金、广东省重大项目课题、广州市重点研发计划、广东省科学院科技项目等8项。获广东省科学院优秀青年科技工作者称号。以一作/通讯发表SCI论文11篇；以第一/二发明人申请发明专利46件（已授权22件，PCT申请4件）；参与开发新产品2个，制定技术标准1件。兼任广东省精准医学应用学会医工结合分会常务委员、广东省、广州市评审专家、广东省高层次人才评审专家、华南理工大学校外硕导。

报告摘要：

Over the past years, the study of bone tissue engineering in the field of regenerative medicine has been the main research topic. Using a three-dimensional (3D) porous degradable scaffold complexed with mesenchymal stem cells (MSCs) and growth factor genes to improve bone tissue repair and regeneration has raised much interest. This study mainly evaluated the osteogenesis of alveolar bone defects of animals in the following experimental groups: sham-operated (SO), 3D printed bioglass (3D-BG), 3D-BG with BMP-2 gene loaded CS (3D-BG+BMP/CS), and 3D-BG with rhesus marrow bone MSCs and BMP/CS (3D-BG+BMP/CS+rBMSCs). Simulated human bone defects with the critical size of 10×10×5mm were established in primates - rhesus monkeys, and in vivo osteogenesis was characterized by X-ray, micro-Computed Tomography, and history. Our results revealed that 3D-BG+rBMSCs+BMP/CS scaffold could improve bone healing best by showing its promote osteogenic properties in vivo. Considering the great bone repair capacity of 3D-BG+BMP/CS+rBMSCs in humanoid primate rhesus monkeys, it could be a promising therapeutic strategy for surgery trauma or accidents, especially for alveolar bones defects.

 Figure 1. Gene and MSCs loaded 3D printed bioglass scaffold to repair alveolar bone defects.