高戈
Coaxial Bioprinting of Blood Vessel Grafts and Vascular Disease Models
报告人:高戈
所在单位:北京理工大学医学技术学院
个人简介：
高戈，北京理工大学医学技术学院助理教授、特别副研究员。博士毕业于韩国浦项工业大学Dong-Woo Cho教授课题组。担任国际期刊Cyborg and Bionic Systems青年编委，曾获国家优秀自费留学生奖学金、ICAMBM Young Investigator Award、POSCO Asian Fellowship等奖励和荣誉。主要研究方向为创新型生物3D打印策略和先进生物墨水，以及面向再生医学和医学检验的仿生组织器官构筑、离体疾病模型和器官芯片开发与应用。系列研究成果在Advanced Functional Materials, Biomaterials, Biofabrication等顶级期刊发表学术论文20余篇。
摘要：
Cardiovascular disease (CVD) is the leading cause of global death, which demands millions of bypass procedures every year to rescue the patients. As the main precursor of CVD, atherosclerosis is a complex inflammatory disorder that still lacks clear pathological mechanisms and effective regenerative therapies. Hence, advanced tissue-engineering techniques are urgently needed to develop vascular bypass graft and disease models for clinical applications and physiopathology research. Coaxial bioprinting has emerged as a novel biofabrication strategy for the rapid tissue-engineering of cell-laden tubular, fibrous, and core-shell spheroid constructs. Due to its unique advantage, this technique showed unparalleled potential for building living vasculatures. Combining with a vascular tissue-specific material formulated from decellularized extracellular matrix bioink, the coaxial bioprinting technique has been utilized to successfully fabricate (1) cell/drug-laden bio-blood-vessels for the recovery of ischemic disease, (2) perfusable and functional vascular in vitro models that can recapitulate the physiopathology of endothelial tissue, (3) geometry-tunable artery equivalents to emulate the early-stage atherosclerotic events, and (4) endothelium/smooth muscle dual-layered blood vessels as small-diameter vascular grafts. These achievements suggest that the coaxial bioprinting is a promising biofabrication strategy that can leverage the strength of 3D bioprinting to build a variety of novel vascular constructs for matching the laboratory and clinical demands.
