Coaxial Bioprinting of Blood Vessel Grafts and Vascular Disease Models
报告人:高戈
所在单位:北京理工大学医学技术学院
个人简介:
高戈,北京理工大学医学技术学院助理教授、特别副研究员。博士毕业于韩国浦项工业大学Dong-Woo Cho教授课题组。担任国际期刊Cyborg and Bionic Systems青年编委,曾获国家优秀自费留学生奖学金、ICAMBM Young Investigator Award、POSCO Asian Fellowship等奖励和荣誉。主要研究方向为创新型生物3D打印策略和先进生物墨水,以及面向再生医学和医学检验的仿生组织器官构筑、离体疾病模型和器官芯片开发与应用。系列研究成果在Advanced Functional Materials, Biomaterials, Biofabrication等顶级期刊发表学术论文20余篇。
摘要:
Cardiovascular disease (CVD) is the leading cause of global death, which demands millions of bypass procedures every year to rescue the patients. As the main precursor of CVD, atherosclerosis is a complex inflammatory disorder that still lacks clear pathological mechanisms and effective regenerative therapies. Hence, advanced tissue-engineering techniques are urgently needed to develop vascular bypass graft and disease models for clinical applications and physiopathology research. Coaxial bioprinting has emerged as a novel biofabrication strategy for the rapid tissue-engineering of cell-laden tubular, fibrous, and core-shell spheroid constructs. Due to its unique advantage, this technique showed unparalleled potential for building living vasculatures. Combining with a vascular tissue-specific material formulated from decellularized extracellular matrix bioink, the coaxial bioprinting technique has been utilized to successfully fabricate (1) cell/drug-laden bio-blood-vessels for the recovery of ischemic disease, (2) perfusable and functional vascular in vitro models that can recapitulate the physiopathology of endothelial tissue, (3) geometry-tunable artery equivalents to emulate the early-stage atherosclerotic events, and (4) endothelium/smooth muscle dual-layered blood vessels as small-diameter vascular grafts. These achievements suggest that the coaxial bioprinting is a promising biofabrication strategy that can leverage the strength of 3D bioprinting to build a variety of novel vascular constructs for matching the laboratory and clinical demands.