苗一非
Decipher the Enigma of Tissue-specific Vasculature with Vascularized Organoid in Health and Disease
报告人:苗一非
所在单位:中国科学院动物研究所
报告人简介:
苗一非，中国科学院动物研究所，人类器官生理病理模拟大科学装置（HOPE）研究员，博士生导师。曾在美国斯坦福大学及辛辛那提儿童医院担任讲师和助理教授。回国后主持和参与科技部重点研发项目和中科院先导项目。相关研究成果先后发表于Cell, Cell Stem Cell，Nature Cardiovascular Research, Circulation，Circulation Research等杂志，总计30余篇。担任Cell Proliferation杂志青年编委, Organoid Research学术副编委。
长期致力于血管内皮细胞的生理病理研究，近年来，专注于解析组织特异性血管网络在组织发育与疾病调控中的功能，并成功开发了一系列基于人iPSC和类器官的器官特异性血管网络模型。基于这些新模型，系统揭示了内皮细胞在先天性心脏病、瓣膜疾病、神经血管疾病、呼吸与消化系统疾病中的新作用，同时发现了多种针对内皮细胞的促器官再生策略。
报告摘要:The vasculature, especially the capillary networks, exhibits remarkable organ-specific specialization to meet local physiological and pathological demands. However, the mechanisms driving this process during human development and disease conditions remain poorly understood. Current models lack the ability to preserve the organotypic characteristics of tissue-specific vasculature in vitro, hindering our understanding of endothelial organ specification under various physiopathological conditions. It has been indicated that the unique microenvironment within each organ plays a critical role in driving the organotypic vascular endothelium and mesenchyme. This study addresses the aforementioned challenge by utilizing the complex cellular niche of the iPSC-derived organoid system to promote the emergence of organ-specific vasculature, thereby recapitulating the intricate cell interactions that underlie development and congenital cardiopulmonary defects. We introduced a broadly applicable platform for generating multilineage organoids with organotypic endothelial and mesenchymal compartments. The complex 3D architecture and cellular diversity of these iPSC-derived organoids present a promising avenue for personalized regenerative therapy, especially for organs with vascular defects.
