Functionalized Biofabrication Technologies for Regeneration of Soft Tissues报告人:
Harbin Institute of Technology (Shenzhen)
Wu Yang, Assistant Professor, School of Mechanical Engineering and Automation, Harbin Institute of Technology (Shenzhen). Dr. Wu received a bachelor's degree from the Department of Mechanical Engineering at Zhejiang University in 2012 and received a Ph.D. from the National University of Singapore in 2016. He served as a postdoctoral fellow at the Pennsylvania State University in the United States from 2017 to 2019. He joined Harbin Institute of Technology (Shenzhen) in January 2020. His research focuses on biofabrication and 3D printing. He has been elected into Shenzhen Overseas High-level Talents Program. He has published more than 30 papers and published 12 first/corresponding-authored SCI articles in the past 5 years. He has been granted 1 Chinese patent and 1 US patent and published 4 book chapters. His research work has been reported by several scientific and technological media such as ISE Magazine. He now serves as an associate editor of the journal Bio-Design and Manufacturing and an editorial board member of the journal BMC Biomedical Engineering. He also serves as a reviewer for several renowned journals in his research field.
Damages of cartilage, tendon, and other soft tissues are common sports injuries, which cover a wide range of patient ages. 3D bioprinting has the ability to prepare artificial tissues, which can control the distribution of cells, extracellular matrix, and other bioactive compounds in different locations of the engineered tissues.
In a series of studies, we focus on the development of bioprinting techniques such as extrusion-based bioprinting, aspiration-assisted bioprinting, and electro-hydrodynamic jet printing, etc. We have investigated the major issues on biofabrication, including 1) the control and optimization of the bioprinting processes, 2) preparation and characterization of bioink with high cell density, 3) fabrication of artificial tissues with anatomically relevant structures and functions, 4) induction of bioprinted tissue in terms of biological functions and physical properties, 5) multi-scale biofabrication and regeneration of soft tissues.
Regarding biomedical applications, we explore the biofabrication of zonally-stratified cartilage with high cell density, which imitates the collagen and cellular organization of the native tissue, and possesses similar mechanical properties of the human cartilage. In addition, we develop a novel fabrication process to generate porous tissues with controllable porosities, which can be differentiated into cartilage and bone tissues. In another case, tendon scaffolds with fibrous structure and enhanced mechanical properties are also developed, in which the cellular organization can be regulated. Through these studies, we use different biofabrication technologies creatively to construct artificial tissues that can be potentially applied for the repair of human tissue defects, which aims to realize the integration of structural mimicry and bio-functionalization.