Dr. Xiao Li is a Professor in the School of Mechanical Engineering at Xi’an Jiaotong University. Dr. Li obtained his doctoral degree from the Department of Mechanical Engineering at McGill University in 2016. He was awarded the CREATE Ph.D. Fellowship from Natural Sciences and Engineering Research Council of Canada from 2013 to 2016. Dr. Li undertook his postdoctoral training in the Department of Chemistry at Stanford University from 2016 to 2021. In 2019, he won the Banting Postdoctoral Fellowship administered by the Canadian government. When Dr. Li joined Xi’an Jiaotong University in 2021, he was selected for the Top Young Talents Program of the university. Dr. Li focuses his research on engineering micro/nanoscale functional structures for biosensors and bioelectronics. By far, he has published 27 articles in scientific journals, including Nature Protocols, Nano Letters, Biosensors & Bioelectronics, Advanced Healthcare Materials, and others.
Engineering Biosensors and Bioelectronics at the Nanoscale
Biosensors and bioelectronics are rooted in manufacturing technology, life science, and medicine, with the ability to decipher biological phenomena such as biomolecular distributions and electrophysiological activities. Accordingly, they constitute effective tools for diagnostics, therapeutics, brain-machine interfaces, and other biomedical applications. An essential task in developing biosensors and bioelectronics is to engineer structures that interface with biological objects from cells to molecules, which requires not only micro/nanoscale manufacturing techniques but also the knowledge of interactions between engineered structures and biological objects. Here we introduce our research on biosensors and bioelectronics featuring nanoscale bio-interfaced structures. (1) Biosensors for molecular detection. We synthesized nanowires for detecting molecules on microfluidic paper-based chips that have great potential for broadening the applications of molecular diagnostics. By adjusting nanowire morphologies to electrochemical sensing mechanisms, we developed biosensors that achieved both high sensitivity and high efficiency in detecting disease markers. (2) Bioelectronics for electrophysiological recording. We fabricated vertical nanostructures on cell culture chips for high-quality recording of action potentials from electrogenic cells. Our studies revealed fundamental mechanisms enabling cells to interact with nanostructures through membrane deformation, which can support the rational design of cell-interfaced bioelectronics.